propranolol!-Inderal!- Oral Uses as Beta Blocker For Anxiety || Propranolol!-10mg-Uses Review By Dr
What Is Inderal (Propanolol)?
Inderal is the brand name for propanolol, a prescription drug used to treat high blood pressure (hypertension).
It's also used to treat severe chest pain (angina), migraines, thickened heart muscle (hypertrophic subaortic stenosis), tremors, a rare tumor called pheochromocytoma, and a movement disorder known as akathisia.
Off-label, Inderal is used to treat esophageal bleeding, aggressive behavior, and panic attacks.
Inderal is a beta blocker. It works by changing the response to nerve impulses in the heart and other body parts, thus making the heart beat more slowly and reducing blood pressure.
As blood pressure lowers, the heart pumps more efficiently.
Sir James Black, who won the Nobel Prize in Medicine in 1988, developed propranolol in the 1960s. The invention is widely viewed as one of the most important contributions to medicine and pharmacology in the 20thcentury.
The Food and Drug Administration (FDA) approved Inderal, initially made by Wyeth, in 1967.
Currently, a number of companies make generic propranolol. A long-acting form for once-a-day dosing has also been approved.
In 2006, the FDA issued a warning letter to Wyeth after receiving reports from consumers who said they found screws and washers inside the bottles of Inderal LA (a long-acting form of the drug).
The FDA cited the Wyeth plant for not following good manufacturing practices and the drug maker took corrective actions.
Inderal for Anxiety
Inderal is prescribed "off-label" for panic attacks.
A study published in 1976 concluded that propranolol could help symptoms of anxiety.
However, a study published in 2013 described a case of an 11-year-old boy with bipolar-1 disorder and panic disorder who developed manic symptoms after taking propranolol.
There is anecdotal evidence that people use propranolol and other beta blockers to help with stage fright, performance anxiety, and public speaking.
Some people chat online about whether propranolol can give you a "high," but most conclude it does not.
Inderal can make angina (chest pains) worse and perhaps cause heart attack if you stop taking it abruptly.
Never stop taking Inderal without first consulting your doctor, who will instruct you on how to safely discontinue its use, if necessary.
If you have bronchospastic lung disease, beta blockers such as Inderal should be taken with caution.
Low blood sugar can occur while taking Inderal, especially after intense exercise.
If you have liver or kidney problems, your doctor will prescribe Inderal with caution.
The medicine may interfere with a glaucoma screening test.
Pregnancy and Inderal
Animal studies have shown that Inderal may have an adverse effect on a developing fetus, but no adequate studies have been done in people.
However, the benefits of taking Inderal during pregnancy may outweigh the risks.
Discuss the pros and cons with your doctor.
Inderal is excreted in breast milk, so breastfeeding mothers should take Inderal with caution. Ask your doctor what course of action is best.
Inderal Side Effects
Common Side Effects of Inderal
Side effects of Inderal that normally don't need immediate medical attention include:
- Restlessness, irritability
- Trouble sleeping, drowsiness, sleepiness, unusual dreams
- Dry mouth
If these persist or bother you, ask your doctor what to do.
Severe Side Effects of Inderal
Certain side effects warrant a call to the doctor right away. These include:
- A cough that produces mucus
- Breathing problems
- Chest tightness
- Abdominal pain, tenderness
- Bloody urine, nose, stools
- Blurry vision
- Skin peeling, blistering, loosening
Thioridazine, an antipsychotic drug, should not be used with Inderal.
Using Inderal with certain other medicines is not usually recommended. These include:
Inderal and Alcohol
Drinking alcohol while taking Inderal may increase the medication’s effects on lowering blood pressure, at least initially.
If you drink while on Inderal, you may feel dizzy, lightheaded or faint, especially when you first start the medicine.
Ask your doctor how to manage alcohol intake while on Inderal.
Inderal and Other Interactions
If you take a multivitamin, do not take it at the same time as Inderal.
Doing so may make the Inderal less effective. Allow two hours between taking the medicine and the vitamin.
Be sure to tell your doctor about any prescription, non-prescription, over-the-counter (OTC), illegal and recreational drugs you may be taking, as well as herbal remedies, nutritional and dietary supplements.
Inderal is available in tablet form in doses of 10, 20, 40, 60 and 80 milligrams (mg).
It is also offered as Inderal LA, a long-acting or extended-release medicine.
Doses vary, depending on the condition being treated.
Symptoms of overdose may include weakness, fainting, or an irregular heartbeat.
Call your doctor right away if you think you’ve taking too much Inderal, or go to the nearest emergency room.
Missed Dose of Inderal
If you miss a dose of Inderal, take it as soon as you can. However, if it is nearly time for your next dose, just resume your regular schedule. Don't double up.
Q: I take Inderal, 60 mg/day. What foods or drinks should I avoid? Wine? grapefruit? Take with food?
A: Inderal doesn't interact with many foods so you shouldn't have to watch what you are eating. However, it is not recommended to intake alcohol while on Inderal because it may increase the concentration of the medication in your blood. Inderal should be taken with a full glass of water at the same time every day. It is best taken before meals. The pill should not be crushed, chewed or broken. Megan Uehara, PharmD
By Kathleen Doheny | Medically Reviewed by Robert Jasmer, MD
Latest Update: 2014-12-03
Copyright © 2014 Everyday Health Media, LLC
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Video: Inderal: My Experience
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